Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

DNA double-strand break repair-pathway choice in somatic mammalian cells.

Scully, Ralph; Panday, Arvind; Elango, Rajula; Willis, Nicholas A.

Nat Rev Mol Cell Biol ; 20(11): 698-714, 2019 11.

Artigo em Inglês | MEDLINE | ID: mdl-31263220

2.

FANCM regulates repair pathway choice at stalled replication forks.

Panday, Arvind; Willis, Nicholas A; Elango, Rajula; Menghi, Francesca; Duffey, Erin E; Liu, Edison T; Scully, Ralph.

Mol Cell ; 81(11): 2428-2444.e6, 2021 06 03.

Artigo em Inglês | MEDLINE | ID: mdl-33882298

3.

The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair.

Adeyemi, Richard O; Willis, Nicholas A; Elia, Andrew E H; Clairmont, Connor; Li, Shibo; Wu, Xiaohua; D'Andrea, Alan D; Scully, Ralph; Elledge, Stephen J.

Mol Cell ; 81(21): 4440-4456.e7, 2021 11 04.

Artigo em Inglês | MEDLINE | ID: mdl-34597596

4.

DNA Polymerase Î¸: Duct Tape and Zip Ties for a Fragile Genome.

Willis, Nicholas A; Scully, Ralph.

Mol Cell ; 63(4): 542-544, 2016 08 18.

Artigo em Inglês | MEDLINE | ID: mdl-27540853

5.

SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging.

Oberdoerffer, Philipp; Michan, Shaday; McVay, Michael; Mostoslavsky, Raul; Vann, James; Park, Sang-Kyu; Hartlerode, Andrea; Stegmuller, Judith; Hafner, Angela; Loerch, Patrick; Wright, Sarah M; Mills, Kevin D; Bonni, Azad; Yankner, Bruce A; Scully, Ralph; Prolla, Tomas A; Alt, Frederick W; Sinclair, David A.

Cell ; 135(5): 907-18, 2008 Nov 28.

Artigo em Inglês | MEDLINE | ID: mdl-19041753

6.

Mechanism of tandem duplication formation in BRCA1-mutant cells.

Willis, Nicholas A; Frock, Richard L; Menghi, Francesca; Duffey, Erin E; Panday, Arvind; Camacho, Virginia; Hasty, E Paul; Liu, Edison T; Alt, Frederick W; Scully, Ralph.

Nature ; 551(7682): 590-595, 2017 11 30.

Artigo em Inglês | MEDLINE | ID: mdl-29168504

7.

Akt-mediated phosphorylation of XLF impairs non-homologous end-joining DNA repair.

Liu, Pengda; Gan, Wenjian; Guo, Chunguang; Xie, Anyong; Gao, Daming; Guo, Jianping; Zhang, Jinfang; Willis, Nicholas; Su, Arthur; Asara, John M; Scully, Ralph; Wei, Wenyi.

Mol Cell ; 57(4): 648-661, 2015 Feb 19.

Artigo em Inglês | MEDLINE | ID: mdl-25661488

8.

RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks.

Elia, Andrew E H; Wang, David C; Willis, Nicholas A; Boardman, Alexander P; Hajdu, Ildiko; Adeyemi, Richard O; Lowry, Elizabeth; Gygi, Steven P; Scully, Ralph; Elledge, Stephen J.

Mol Cell ; 60(2): 280-93, 2015 Oct 15.

Artigo em Inglês | MEDLINE | ID: mdl-26474068

9.

Rad51 recruitment and exclusion of non-homologous end joining during homologous recombination at a Tus/Ter mammalian replication fork barrier.

Willis, Nicholas A; Panday, Arvind; Duffey, Erin E; Scully, Ralph.

PLoS Genet ; 14(7): e1007486, 2018 07.

Artigo em Inglês | MEDLINE | ID: mdl-30024881

10.

BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks.

Willis, Nicholas A; Chandramouly, Gurushankar; Huang, Bin; Kwok, Amy; Follonier, Cindy; Deng, Chuxia; Scully, Ralph.

Nature ; 510(7506): 556-9, 2014 Jun 26.

Artigo em Inglês | MEDLINE | ID: mdl-24776801

11.

BRCA1 is required for postreplication repair after UV-induced DNA damage.

Pathania, Shailja; Nguyen, Jenna; Hill, Sarah J; Scully, Ralph; Adelmant, Guillaume O; Marto, Jarrod A; Feunteun, Jean; Livingston, David M.

Mol Cell ; 44(2): 235-51, 2011 Oct 21.

Artigo em Inglês | MEDLINE | ID: mdl-21963239

12.

FANCJ helicase controls the balance between short- and long-tract gene conversions between sister chromatids.

Nath, Sarmi; Somyajit, Kumar; Mishra, Anup; Scully, Ralph; Nagaraju, Ganesh.

Nucleic Acids Res ; 45(15): 8886-8900, 2017 Sep 06.

Artigo em Inglês | MEDLINE | ID: mdl-28911102

13.

Complex Breakpoints and Template Switching Associated with Non-canonical Termination of Homologous Recombination in Mammalian Cells.

Hartlerode, Andrea J; Willis, Nicholas A; Rajendran, Anbazhagan; Manis, John P; Scully, Ralph.

PLoS Genet ; 12(11): e1006410, 2016 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-27832076

14.

53BP1 Protects against CtIP-Dependent Capture of Ectopic Chromosomal Sequences at the Junction of Distant Double-Strand Breaks.

Guirouilh-Barbat, Josée; Gelot, Camille; Xie, Anyong; Dardillac, Elodie; Scully, Ralph; Lopez, Bernard S.

PLoS Genet ; 12(10): e1006230, 2016 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-27798638

15.

Correction: Complex Breakpoints and Template Switching Associated with Non-canonical Termination of Homologous Recombination in Mammalian Cells.

Hartlerode, Andrea J; Willis, Nicholas A; Rajendran, Anbazhagan; Manis, John P; Scully, Ralph.

PLoS Genet ; 12(12): e1006509, 2016 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-27959912

16.

The tandem duplicator phenotype as a distinct genomic configuration in cancer.

Menghi, Francesca; Inaki, Koichiro; Woo, XingYi; Kumar, Pooja A; Grzeda, Krzysztof R; Malhotra, Ankit; Yadav, Vinod; Kim, Hyunsoo; Marquez, Eladio J; Ucar, Duygu; Shreckengast, Phung T; Wagner, Joel P; MacIntyre, George; Murthy Karuturi, Krishna R; Scully, Ralph; Keck, James; Chuang, Jeffrey H; Liu, Edison T.

Proc Natl Acad Sci U S A ; 113(17): E2373-82, 2016 Apr 26.

Artigo em Inglês | MEDLINE | ID: mdl-27071093

17.

Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion.

Juvekar, Ashish; Hu, Hai; Yadegarynia, Sina; Lyssiotis, Costas A; Ullas, Soumya; Lien, Evan C; Bellinger, Gary; Son, Jaekyoung; Hok, Rosanna C; Seth, Pankaj; Daly, Michele B; Kim, Baek; Scully, Ralph; Asara, John M; Cantley, Lewis C; Wulf, Gerburg M.

Proc Natl Acad Sci U S A ; 113(30): E4338-47, 2016 07 26.

Artigo em Inglês | MEDLINE | ID: mdl-27402769

18.

RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci.

Hu, Yiduo; Scully, Ralph; Sobhian, Bijan; Xie, Anyong; Shestakova, Elena; Livingston, David M.

Genes Dev ; 25(7): 685-700, 2011 Apr 01.

Artigo em Inglês | MEDLINE | ID: mdl-21406551

19.

A histone code for DNA repair.

Scully, Ralph.

Nat Rev Mol Cell Biol ; 11(3): 164, 2010 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-20213875

20.

Variants of uncertain clinical significance in hereditary breast and ovarian cancer genes: best practices in functional analysis for clinical annotation.

Monteiro, Alvaro N; Bouwman, Peter; Kousholt, Arne N; Eccles, Diana M; Millot, Gael A; Masson, Jean-Yves; Schmidt, Marjanka K; Sharan, Shyam K; Scully, Ralph; Wiesmüller, Lisa; Couch, Fergus; Vreeswijk, Maaike P G.

J Med Genet ; 57(8): 509-518, 2020 08.

Artigo em Inglês | MEDLINE | ID: mdl-32152249

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